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The obtained in-vitro dissolution data were fitted in different models and for F2 batch (higher concentration of xanthan gum) the highest correlation was found to korsesmeyer-peppas (R 2 >0.9022), which indicates the drug diffusion may takes place by erosion mechanism.
In Situ Gel of Atorvastatin Graphical Abstract and remains insoluble in aqueous solutions due to the MATERIALS AND METHODS chemical or physical cross linking of individual polymer Atorvastatin was obtained as a gift samples from Micro- chains. This type of gel formulations are applied as a labs, Bangalore.
Formulation F4 and F6 (higher concentration of guar gum and Carrageenan) the data were fitted in to zero order profile where R 2 values were found to be 0.9244 and 0.9348 indicates the diffusion mechanism of drug release.
Generally the different techniques matrix system . the drug class known as statins. Atorvastatin calcium rate-limiting step in cholesterol bio synthesis. This tu rn lowers the total amount of LDL cholesterol. concentration. All the ingredients shown in weighed, shifted and blended in mixer uniformly.
Last Update: Oct 2021
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